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The rarity of eyes that are rarely seen in humans (for example, one eye is blue, the other eye is green, etc.) is called heterochromia. The density and distribution of the melanin pigment, which gives color to the hair, skin and eyes, determines the color of the eye. Brown eye means high amount of melanin and colored eye means low amount of melanin. If the density or amount of melanin in the iris layer of both eyes is different, the eyes are also in different colors, that is, the case of heterochromia. As a result of changes in the expression of genes responsible for determining eye color (producing functional proteins using genetic information on DNA), diseases such as Waardenburg syndrome, and a trauma that occurs at the time of birth or later in life, heterochromia can be seen in individuals. Differences in pigmenting in the iris layer during embryo development can also cause heterochromia.